PSA (Pressure Swing Adsorption) oxygen generator mainly uses the difference in the adsorption capacity of adsorbents for nitrogen, oxygen and other gases in the air at different pressures to produce oxygen. In the biopharmaceutical process, oxygen purity is crucial. NEWTEK PSA oxygen generator can produce oxygen with a purity of about 90% - 95%. After our technological breakthrough, it can reach a purity of more than 99.5%. Its working principle is that under a certain pressure, air passes through an adsorption tower equipped with molecular sieve adsorbents. The molecular sieve preferentially adsorbs impurity gases such as nitrogen, and oxygen is collected through the adsorption tower. This process regenerates the adsorbent through periodic changes in pressure, thereby continuously producing oxygen.
NTK93 Series PSA Oxygen Plant Model Selection |
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No. |
Models |
Capacity (Nm3/hr) |
Purity |
Power consumption of 1Nm3 oxygen produced (kw/h) |
Number of bottles filled in 12 hours (pcs) |
Operator needed |
| 1 | NTK-5P | 5 | 93%+-3% | 3.54 | 10 | 2 |
| 2 | NTK-10P | 10 | 93%+-3% | 2.52 | 20 | 2 |
| 3 | NTK-15P | 15 | 93%+-3% | 2.31 | 30 | 2 |
| 4 | NTK-20P | 20 | 93%+-3% | 2.13 | 40 | 2 |
| 5 | NTK-25P | 25 | 93%+-3% | 2.01 | 50 | 2 |
| 6 | NTK-30P | 30 | 93%+-3% | 2.09 | 60 | 2 |
| 7 | NTK-40P | 40 | 93%+-3% | 1.81 | 80 | 2 |
| 8 | NTK-50P | 50 | 93%+-3% | 1.94 | 100 | 2 |
| 9 | NTK-60P | 60 | 93%+-3% | 1.62 | 120 | 2 |
| 10 | NTK-80P | 80 | 93%+-3% | 1.92 | 160 | 2 |
| 11 | NTK-100P | 100 | 93%+-3% | 1.83 | 200 | 2 |
| Design basis: Altitude：≤500m;RH：≤80%;Temperature：0℃-38℃;Filling pressure: 150Bar 40L Type Standard Cylinder | ||||||
Application of NEWTEK PSA oxygen generator in cell culture
Provide a suitable growth environment for cells: In the cell culture process, oxygen is a necessary substance for cell respiration. Many cell lines, such as mammalian cells, require a suitable oxygen concentration during culture to maintain their normal metabolism and growth. By providing a stable oxygen supply through the PSA oxygen generator, the oxygen content in the cell culture environment can be precisely controlled. For example, for some oxygen-sensitive stem cell cultures, controlling the oxygen concentration within the range of 3% - 8% can promote the proliferation and differentiation of stem cells.
Improve the efficiency and quality of cell culture: A suitable oxygen supply helps to improve cell vitality and product expression. In the production of monoclonal antibodies, the high-quality oxygen provided by the PSA oxygen generator can be used to place hybridoma cells in a good culture environment, which can increase the production of monoclonal antibodies by 20% - 30%. This is because sufficient and appropriate oxygen can ensure the smooth progress of the cell's energy metabolism process, thereby promoting cell growth and product synthesis.
Application in fermentation engineering
Promote microbial fermentation: In the process of microbial fermentation to produce drugs, such as the production of antibiotics, enzyme preparations, etc., oxygen is one of the key factors affecting the fermentation effect. Many microorganisms, such as Penicillium, need sufficient oxygen for aerobic respiration when producing penicillin. The PSA oxygen generator can provide high-purity oxygen for the fermentation tank to ensure sufficient oxygen supply during the fermentation process. For example, during the penicillin fermentation process, appropriately increasing the oxygen supply to keep the dissolved oxygen concentration in the fermentation broth at an appropriate level (such as 40% - 60% saturation) can increase the penicillin yield by 30% - 50%.
Optimizing fermentation process control: Compared with traditional ventilation methods, PSA oxygen generators can more accurately control the supply and rate of oxygen. This helps to maintain a stable dissolved oxygen level during the fermentation process and avoid fermentation abnormalities caused by insufficient or excessive oxygen. For example, in the yeast fermentation process of producing recombinant proteins, by accurately controlling the oxygen supply, the growth cycle of yeast cells can be made more stable and the fermentation cycle can be shortened by about 10% - 15%.
Application in pharmaceutical packaging
Preventing drugs from oxidizing and deteriorating: During the pharmaceutical packaging process, some drugs are easily oxidized and deteriorated by oxygen. For example, fat-soluble drugs containing unsaturated fatty acids, easily oxidized vitamins, etc. The oxygen produced by the PSA oxygen generator can be used to replace the packaging container with inert gas before packaging. The air in the container is first extracted, and then filled with a mixed gas such as nitrogen and a small amount of carbon dioxide (with extremely low oxygen content), thereby extending the shelf life of the drug. In some soft capsule drug packaging, the shelf life of the drug can be extended from the original 1-2 years to 2-3 years after adopting this gas replacement technology.
Quality control and compliance
Compliance with Good Manufacturing Practice (GMP) requirements: In the biopharmaceutical industry, strict compliance with GMP is the key to ensuring drug quality and safety. PSA oxygen generators can provide traceable oxygen supply records, including oxygen purity, flow, pressure and other parameters. These records are very important for quality control and auditing of the drug production process. At the same time, the equipment itself can be verified and maintained regularly to ensure that its performance meets GMP standards and provide a reliable source of oxygen for biopharmaceutical production.